澳门在线威尼斯官方-威尼斯威尼斯国际网址

澳门在线威尼斯官方
师资力量

曾小明     教授, 博士生导师

研究方向:金属有机化学 (单胺基卡宾配体和铬催化研究)

联系方式:(+86)-13281058102          Email:zengxiaoming@scu.edu.cn

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简历

2017.05—至今           澳门在线威尼斯官方从事教学与科研工作,教授、博士生导师

2012.012017.04      西安交通大学前沿科学技术研究院从事科研工作,教授、博士生导师

2010.042011.12      东京大学化学系,JSPS博士后,合作导师:Eiichi Nakamura 教授

2007.092009.09      加州大学河滨分校化学系,联合培养博士,导师:Guy Bertrand 教授

2004.092009.12      澳门在线威尼斯官方有机化学专业攻读博士学位,导师:罗美明教授

2002.092004.07      广东省新兴县华侨中学从事高中化学教学工作

1998.092002.07      四川师范大学化学学院应用化学专业本科学习

学术任职:任Current Chinese Chemistry Journal杂志编委(2019–目前)Elsevier数据库旗下期刊Heliyon的国际编委(2015–2019)

主要研究方向

 





(1)单胺基卡宾配体促进的铑和铬催化研究

与常用的双胺基氮杂环卡宾比较,单胺基卡宾拥有较高能级的HOMO和较低能级的LUMO分子轨道,表现出强的亲核和亲电性,具有作为优秀配体的潜质。研究方向之一是利用这类卡宾的富电特性促进金属催化、解决合成中突出的化学与立体选择性难题。

(2) 低价铬在惰性化学键活化与氢功能化中的催化基础研究

金属铬全球储量超过120亿吨,是地壳中含量最丰富的五种过渡金属之一。相较于第一过渡系其它金属如铁、钴、镍、锰及铜的二氯化物,二氯化铬的毒性更低(Organometallics 2017,   36, 4071)。研究方向之一是探索金属铬独特的催化活性与发展铬催化合成策略,揭示铬催化的特点和规律,解决惰性化学键活化及不饱和化合物氢功能化中存在的挑战。

 

主要工作业绩

(1) 单胺基卡宾配体在芳烃去芳香性及炔烃选择性催化氢化中的应用基础研究:

构建单胺基卡宾促进的芳烃去芳香性氢化的催化体系,为环已酮有机化工原料及顺式的多取代环烷烃基础化学品的快速、选择性地制备提供合成策略。

(2) 铬在惰性化学键活化及氢功能化中的催化基础研究:

构建铬催化惰性化学键偶联体系,揭示低价铬螯合切断惰性碳-氧、碳-氮键的特征,发现两种惰性化学键还原偶联模式。

     作为主要贡献人分别在Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat.   Commun., ACS Catal., Chem. Common., Org. Lett., Organometallics等刊物上发表论文五十余篇,其中单篇最高他引270余次,7篇论文他引超过一百次,被同行正面评价和推介近二十次。

主要奖励和荣誉

2020年获得“Thieme Chemistry   Journal Award

2019年获得“ACP Lectureship   Awards (Japan)

2019年获得“ACP Lectureship   Awards (Singapore)

2018年入选第十二批四川省学术和技术带头人后备人选

2016年入选西安交通大学青年拔尖人才计划A

2015年获得美国化学会三年会员奖励

2010年获得日本学术振兴会外国人特别研究员奖学金

2007年获得中国留学基金委公派留学奖学金

代表性成果 (获奖成果、专著、论文、专利)

一.发表主要论文

1.   Jinghua   Tang, Liu Leo Liu, Shangru Yang, Xuefeng Cong, Meiming Luo, and Xiaoming Zeng*

Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)–O Bonds Enabled by Chromium   Catalysis

J. Am. Chem. Soc. 2020, DOI: 10.1021/jacs.0c00283. [Link]

       

2.   Xiaoming Zeng*

Recent Advances in  Chromium-Catalyzed Organic Transformations

Synlett 2020, 31 (3),  205–210. [Link] 

                    

3.   Xue Zhang, Liang Ling, Meiming Luo, and Xiaoming Zeng*

Accessing Equatorially   Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and   Saturated Heterocycles by Preferential Hydrogen-Addition to the Substitution Sites for Dearomatization

Angew. Chem. Int. Ed. 2019, 58   (47), 16785–16789. [Link] 

    

4.   Zhi   Rong, Meiming Luo,* and Xiaoming Zeng*

Modular Arene Difunctionalization by Sequential Cleavage of Unactivated C–O and C–H Bonds   in One Pot with Chromium Catalysis

Org. Lett. 2019, 21(17),   6869–6873.   [Link] 

       

5.   Hong Meng, Sen Gao, Meiming Luo,* and Xiaoming Zeng*

Iron and Phenol CoCatalysis for Rapid Synthesis of Nitriles under Mild Conditions

Eur. J. Org. Chem. 2019, 2019 (28)   4617?4623. [Link] 

6.    Bo Han, Pengchen Ma, Xuefeng Cong, Hui Chen,* and Xiaoming Zeng*

Chromium- and Cobalt-Catalyzed,   Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study

J. Am. Chem. Soc. 2019, 141   (22), 9018?9026. [Link] 

       

7.    Liang Ling, Yuan He, Xue Zhang, Meiming Luo, and Xiaoming Zeng*

Hydrogenation of (Hetero)aryl   Boronate Esters with a Cyclic (Alkyl)(amino)carbene-Rhodium Complex: Direct   Access to cis-Substituted Borylated Cycloalkanes and Saturated   Heterocycles

Angew. Chem. Int. Ed. 2019, 58 (20), 6554–6558. [Link] 

     

8.      Liang Ling, Changpeng Chen, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed Activation of Acyl C–O Bonds with Magnesium for Amidation of Esters with Nitroarenes

Org. Lett. 2019, 21 (6), 1912–1916. [Link] 

      

9.     Jinghua Tang, Xuejiao J. Gao, Huarong Tang,* and Xiaoming Zeng*

Dioxygen activation with stable N-heterocyclic carbenes

Chem. Commun. 2019, 55(11), 1584–1587. [Link] 

       

10.   Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, and Xiaoming Zeng*

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Nat. Commun. 2018, 9,   4637. [Link] 

      

11.     Jinghua Tang, Pei Liu, and Xiaoming Zeng*

N-Heterocyclic carbene–chromium-catalyzed alkylative cross-coupling of benzamide derivatives with aliphatic bromides

Chem. Commun. 2018, 54(67),   9325–9328. [Link]

      

12.     Fei Fan, Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed   Regioselective Kumada Arylative Cross-Coupling of C(aryl)–O Bonds with a Traceless Activation Strategy

J. Org. Chem. 201883(21),   13549–13559. [Link]

      

13.     Changpeng  Chen, Pei Liu, Meiming Luo, and Xiaoming Zeng*

Kumada Arylation of Secondary Amides Enabled by Chromium Catalysis for Unsymmetric Ketone Synthesis under   Mild Conditions

ACS Catal. 20188(7),   5864–5868. [Link]

      

14.     Yuan He, Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

Regioselective and Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis of the 5,6,7,8-Tetrahydronaphthol Core

Org. Lett. 201820(14),   4159–4163. [Link]

   

15.     Lei Jia, Qiang Tang, Meiming Luo,* and Xiaoming Zeng*

Direct ortho-Selective Amination of 2-Naphthol and Its Analogues with Hydrazines

J. Org. Chem. 201883(9), 5082–5091.   [Link]

 

16.     Xuefeng Cong, Fei Fan, Pengchen Ma, Meiming Luo, Hui Chen,* and Xiaoming Zeng*

Low-Valent, High-Spin Chromium-Catalyzed Cleavage of Aromatic Carbon–Nitrogen Bonds at Room   Temperature: A Combined Experimental and Theoretical Study

J. Am. Chem. Soc. 2017, 139(42), 15182?15190. [Link]

       

17.  Lei  Jia, Qiang Tang, Meiming Luo,* and Xiaoming Zeng*

One-Step Synthesis of Unsymmetric 1,1’-Biaryl-2,2'-diamines by the Reaction of 2-Naphthols with   Aryl Hydrazines

Chin. J. Org. Chem. 2018, 38,   443–450. [Link]?

18.  Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed, Regioselective   Cross-Coupling of C–O Bonds Using Organic Bromides as Reactants

Synlett, 2017, 28(19),   2577–2580. (Invited for cluster of “C–O bond activation”) [Link]

19.   Sen Gao, Liming Gao, Hong Meng, Meiming Luo,* and Xiaoming Zeng*

Iron-Catalyzed Synthesis of  Benzoxazoles by Oxidative Coupling/Cyclization of Phenol Derivatives with   Benzoyl Aldehyde Oximes

Chem. Commun., 2017, 53(71),   98869889. [Link]

20.  Changpeng Chen, and Xiaoming Zeng*

Ruthenium-Catalyzed   Alkynylation of Benzoic Acids Mediated by a Weakly-Coordination Directing   Auxiliary

Eur. J. Org. Chem. 2017, 2017(32), 4749–4752.   [Link]

21.  Changpeng Chen, Pei Liu, Jinghua Tang, Gongda Deng, and Xiaoming Zeng*

Iridium-Catalyzed, Weakly Coordination-Assisted Ortho-Alkynylation of (Hetero)aromatic   Carboxylic Acids without Cyclization

Org. Lett. 201719(10),   2474–2477. [Link]

22.  Pei Liu, Jinghua Tang, and Xiaoming Zeng*

Site-Selective Silylation of   Aliphatic C–H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila   Benzamides

Org. Lett. 2016, 18(21),   5536–5539. [Link] 

23.   Bin Rao, Jinghua Tang, and Xiaoming Zeng*

Synthesis of 2-Benzylphenyl   Ketones by Aryne Insertion into Unactivated C–C Bonds

Org. Lett. 2016, 18(7),   1678–1681. [Link] 

24.   Xuefeng Cong, Shengxian Zhai, and Xiaoming Zeng*

Low-Valent Cobalt-Catalyzed C–H   Allylation

Org. Chem. Front. 2016, 3(6),   673–677. (Invited as “2015 Emerging Investigator by OCF”) [Link] 

25.     Yuexuan   Li, Gongda Deng, and Xiaoming Zeng*

Chromium-Catalyzed   Regioselective Hydropyridination of Styrenes

Organometallics 201635(5),   747–750. [Link]

      

26.     Bin   Rao, Jinghua Tang, Yu Wei, and Xiaoming Zeng*

Ring Expansion via Cleavage of   Benzylic C–C Bonds Enabling Direct Synthesis of Medium Ring-fused   Benzocarbocycles

Chem.–Asian J. 201611(7),   991–995. [Link]

27.      Xuefeng  Cong, Huarong Tang, and Xiaoming Zeng*

Regio- and Chemoselective Kumada–Tamao–Corriu Reaction of Aryl Alkyl Ethers Catalyzed by Chromium Under   Mild Conditions

J. Am. Chem. Soc. 2015137(45),   14367–14372. [Link] (Highlights by Synfacts, 2016, 12, 0192;   ChemInform, 2016, 47, 21-126)

      

28.     Yu Wei, and Xiaoming Zeng*

Catalytic Strategies toward Selective Hydrogenation of Aromatic Ketones and Phenols: Facile Synthesis of   Cyclohexyl Ketones

Synlett 2016, 27(5),   650–655. (Invited Synpacts article) [Link]

            

29.     Bin Rao, Huarong Tang, Xiaoming Zeng*, Liu Liu, Mohand Melaimi and Guy   Bertrand*

Cyclic (Amino)(aryl)carbenes (CAArCs) as Strong σ-Donating and π-Accepting Ligands for Transition   Metals

Angew. Chem. Int. Ed. 2015, 54(49),   14915–14919. [Link]

           

30.     Yu   Wei, Bin Rao, Xuefeng Cong, and Xiaoming Zeng*

Highly Selective Hydrogenation  of Aromatic Ketones and Phenols Enabled by Cyclic (Amino)(alkyl)carbene   Rhodium Complexes

J. Am. Chem. Soc. 2015, 137(29),   9250–9253. [Link]

(Highlights by Chin. J. Org. Chem. 2015, 35, 2019; ChemInform, 2016, 47,   03-038)

           

31.     Xiaoming Zeng* and Xuefeng Cong

Chromium-Catalyzed Transformations Using Grignard Reagents: New Opportunities for Cross-Coupling   Reactions

Org. Chem. Front. 2015, 2(1),   69–72. [Link] 

32.     Xuefeng   Cong, Yuexuan Li, Yu Wei, and Xiaoming Zeng*

Nickel-Catalyzed C–H Coupling with Allyl Phosphates: A Site-Selective Synthetic Route to Linear Allylarenes

Org. Lett. 2014, 16(15),   3926–3929. [Link] (Highlight by ChemInform, 2015, 46,   05-054)

33.     Xuefeng   Cong and Xiaoming Zeng*

Iron-Catalyzed,   Chelation-Induced Remote C–H Allylation of Quinolines via 8-Amido Assistance

Org. Lett. 2014, 16(14),   3716–3719. [Link] (Highlight by ChemInform, 2015, 46,   02-047)

34.     Yu Wei, Huarong Tang, Xuefeng Cong, Bin Rao, Chao Wu* and Xiaoming   Zeng*

Pd(II)-Catalyzed Intermolecular Arylation of Unactivated C(sp3)–H Bonds with Aryl Bromides Enabled   by 8-Aminoquinoline Auxiliary

Org. Lett. 2014, 16(8),   2248–2251. [Link] (Highlight by ChemInform, 2014, 45,   41-085)

35.     Bin Rao and Xiaoming Zeng*

Aminocyanation by the Addition of N–CN Bonds to Arynes: Chemoselective Synthesis of 1,2-Bifunctional   Aminobenzonitriles

Org. Lett., 2014, 16(1),   314–317. [Link] (Highlights by ChemInform, 2014, 45,   23-095; Org. Chem. Highlights 2014, October 13)

36.     Xuefeng Cong, Huarong Tang, Chao Wu*, and Xiaoming Zeng*

Role of Mono-N-Protected Amino   Acid Ligands in Pd(II)-Catalyzed Dehydrogenative Heck Reactions of   Electron-Deficient (Hetero)Arenes: Experimental and Computational Studies

Organometallics, 2013, 32(21),   6565–6575. [Link]  

37.     Yu Wei, Jinghua Tang, Xuefeng Cong, and Xiaoming Zeng*

Practical Metal-Free Synthesis   of Chalcone Derivatives via a Tandem   Cross-Dehydrogenative-Coupling/Elimination Reaction

Green Chem. 2013, 15(11),   3165–3169. [Link] (Highlight by ChemInform, 2014, 45,   12-079)

38.      Xiaoming Zeng*

Recent Advances in Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon–Carbon Multiple Bonds

Chem. Rev. 2013, 113(8), 6864–6900. [Link]  (ESI highly cited paper)

 

39.     Pei   Guo, Xiaoming Zeng, Si Chen, and Meiming Luo*

Au(I)–N-heterocyclic carbene   complex-catalyzed synthesis of 1-substituted benzo[b][1,4]diazepines   from N-substituted o-phenylenediamines and terminal alkynes

J. Organomet. Chem. 2013, 751, 438–442. [Link]  

40.     Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*

Iron-Catalyzed Regio- and Stereoselective Chloro-sulfonylation of Terminal Alkynes with Aromatic Sulfonyl Chlorides

Org. Lett. 2012, 14(3),  954–956. [Link] (Highlight by ChemInform, 2012, 43, 23-088)

41.     Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*

Synthesis of Functionalized 1H-Indenes via Copper-Catalyzed Arylative Cyclization of Arylalkynes with   Aromatic Sulfonyl Chlorides

J. Am. Chem. Soc. 2011, 133(44),   17638–17640. [Link] 

42.     Laurean Ilies, Quan Chen, Xiaoming Zeng, and Eiichi Nakamura*

Cobalt-Catalyzed Chemoselective   Insertion of Alkene into the ortho-C–H Bond of Benzamide

J. Am. Chem. Soc. 2011, 133(14),   5221–5223. [Link] 

43.     Xiaoming Zeng, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*

Serendipitous Discovery of the   Catalytic Hydroammoniumation and  Methylamination of Alkynes

Angew. Chem., Int. Ed. 2010, 49(5),   942–945. [Link]  

44.     Xiaoming Zeng, Guido D. Frey, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*

Synthesis of a Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes, and   Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component   Preparation of 1,2-Dihydroquinoline Derivatives

J. Am. Chem. Soc. 2009, 131(24),   8690–8696. [Link] 

45.     Xiaoming Zeng, Guido D. Frey, Shazia Kousar, and Guy Bertrand*

A Cationic Gold(I) Complex as a General Catalyst for the Intermolecular Hydroamination of Alkynes:   Application to the One-Pot Synthesis of Allenes from Two Alkynes and a   Sacrificial Amine

Chem.–Eur. J. 2009, 15(13),   3056–3060. [Link] 

46.     Xiaoming Zeng, Michele Soleilhavoup, and Guy Bertrand*

Gold-Catalyzed Intermolecular   Markovnikov Hydroamination of Allenes with Secondary Amines

Org. Lett. 2009, 11(15),  3166–3169. [Link] 

47.     Xiaoming Zeng, Tongxin Zhang, Yuancheng Qin, Zhijun Wei, and Meiming Luo*

Synthesis of a Carbene Transfer   Organometallic Polymer and Application to Forming a Recyclable Heterogeneous   Catalyst for the Suzuki Reactions of Arylchlorides

Dalton Trans. 2009, 2009 (39), 8341–8348. [Link]   

48.     Sujuan Zhang, Xiaoming Zeng, Zhijun Wei, Dongbing Zhao, Tairan Kang, Weifeng Zhang, Mei Yan, and Meiming Luo*

Desulfitative Suzuki   Cross-Couplings of Arylsulfonyl Chlorides and Boronic Acids Catalyzed by a   Recyclable Polymer-Supported N-Heterocyclic Carbene-Palladium Complex   Catalyst

Synlett 2006, 18(12),   1891–1894. [Link]   

49.     Chun Yan, Xiaoming Zeng, Weifeng Zhang, and Meiming Luo*

Polymer-Supported N-Heterocyclic Carbene–Rhodium Complex Catalyst for the Addition of   Arylboronic Acids to Aldehydes

J. Organomet. Chem. 2006, 691(15),   3391–3396. [Link]

二.授权专利

1.  曾小明、韩波、罗美明;一种铬盐/甲基溴化镁选择性催化氢化多环芳烃的方法,中国,专利号:ZL 2017 1 0396279.3,授权日期2019-07-09,申请日期2017-05-31.

2.  曾小明、韩波、罗美明;基于钴盐选择性催化氢化多环芳烃的方法,中国,专利号:ZL 2017 1 0396265.1,授权日期2019-07-09,申请日期2017-05-31.

 

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